I recently learned about your excellent work in producing the Nano Risk Framework.
It could be that your management of the basic information could be enhanced by adopting the approach and the techniques of the Guidance produced by the Netherlands Environment Assessment Agency. You can learn about it on the website www.nusap.net, go to Sections and then RIVM/MNP Uncertainty Guidance. For a more recent version, I attach a draft paper [PDF].
I am sure that the lead authors of the paper will be very pleased to discuss the possible application of the Guidance to your framework.